
In 1789 in Hallowell, Maine, the midwife Martha Ballard is called to examine a man found frozen in the Kennebec River, one of two respected men accused months earlier of rape, and her diary and her determination set her against the town's powerful.
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In 1791 Nella runs a hidden London apothecary selling poisons to women who want rid of the men who wronged them, and two centuries later Caroline, alone on the anniversary trip she meant to take with her husband, finds an old apothecary vial in the Thames mud.

During an ice storm in rural Vermont in 1981, midwife Sibyl Danforth performs an emergency caesarean on a mother she believes has died in labour and is charged with manslaughter; her daughter Connie, fourteen at the time and now an obstetrician, tells the story of the trial.

In northern Iceland in 1829, Agnes Magnúsdóttir, condemned to death for murder, is sent to wait out the winter on a district officer's farm, where the family that resents her slowly begins to hear her side.

An orphanage obstetrician in wartime Maine who also quietly performs abortions raises a favourite boy into the doctor who will eventually have to decide what the cider-house rules were for.

Ruth Jefferson, a labour and delivery nurse with twenty years' experience, is barred from caring for a newborn because his parents are white supremacists, and when the baby goes into distress while she is alone with him, she is charged with his death.

Thirteen-year-old Anna Fitzgerald was conceived as a genetic match for her sister Kate, who has leukemia, and has given blood and marrow all her life; when her parents expect her to give a kidney, she hires a lawyer and sues them for the right to decide.

Three women's lives converge on the Ravensbrück concentration camp: Caroline Ferriday, a New York socialite volunteering at the French consulate; Kasia Kuzmerick, a Polish teenager sent there for her part in the resistance; and Herta Oberheuser, a young German doctor who takes a post there.

A servant girl in nineteenth-century Canada is convicted of double murder, and a doctor tries to determine whether she's a victim, a madwoman, or a killer.

In 1612 Lancashire, seventeen-year-old Fleetwood Shuttleworth, pregnant again after miscarriages that nearly killed her, hires a midwife named Alice Gray just as the Pendle witch accusations begin.

In Crosby, Maine, the lawyer Bob Burgess takes on the case of a lonely man suspected of killing his mother, while his friend, the writer Lucy Barton, visits the elderly Olive Kitteridge, who has stories she wants to tell.

In 1617, after a storm drowns nearly every man of a fishing village on the Norwegian island of Vardø, the women learn to fend for themselves, until a witch-hunter arrives with his young Scottish wife.

On her eleventh birthday in Charleston in 1803, Sarah Grimké is given ten-year-old Hetty 'Handful' Grimké as her maid, and over thirty-five years the two women, one who will become an abolitionist and one enslaved in her household, tell their parallel stories.